Research project

"Seeing is Believing": Visualization of biomolecules offers a fascinating and powerful way to observe complex processes such as binding events and folding pathways in real-time. Our research is dedicated to unraveling the dynamic behavior of catalytically active RNAs and understanding how their structures are intricately linked to their functions. To achieve this, we employ a range of innovative RNA labeling strategies that allow us to explore these processes at the single-molecule level. Advanced techniques like Förster Resonance Energy Transfer (smFRET) and Fluorescence Correlation Spectroscopy (FCS) provide us with a window into the molecular choreography of these vital biomolecules, offering unprecedented insights into their roles in biological systems.
Behind the Lab Coat: My Inspirations and Passions
Education
- Since 2020 Scientist in Roland Sigel's lab
- 2018 - 2020 Postdoctoral fellow in Roland Sigel's lab
- 2012 - 2018 Ph.D. in Roland Sigel's lab: "Combining Single-Molecule with Ensemble Fluorescence Experiments to Disentangle the Interplay of Folding and Activity of a Group II Intron Ribozyme"
- 2011: M.Sc. at the Institute of Inorganic Chemistry & Biochemistry, University of Zurich, Prof. G. R. Patzke, Topic: "Microscopic Investigations of a Potential Drug Carrier System for Bioactive Polyoxometalates"
- 2005: B.Sc. in Biotechnology, FH-Lausitz, University of Applied Sciences, Germany, and at the Institute of Medical Microbiology, University of Zurich, Prof. E.C. Böttger, Topic: "Cloning and Purification of Ribosomal Proteins of Mycobacterium smegmatis "
Research Experiences
- 2013 – 2017 Administrative assistant for COST action CM1105: Functional metal complexes that bind to biomolecules
- 2010 – 2012 Research Associate at the biotech company Molecular Partners, Zürich, Field: "Ribosome display selections, Protein screening, expression, purification, and characterization"
- 2006 – 2010 Research Technician at the Institute of Inorganic Chemistry, University of Zurich, Prof. Roland K. O. Sigel, Topic: "Metal ion‐RNA‐Interaction"