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Ribozymes are RNA molecules that can catalyse chemical reactions. To achieve their activity, ribozymes must fold into a specific and complex 3-dimensional structure. RNA binding proteins, such as Mss116, facilitate this folding process. However, the exact mechanism by which Mss116 promotes the formation of the active conformation is unclear. In my project, I'm excited to combine two single-molecule techniques to identify this mechanism.
| 2024 – Present | Doctorate in Chemical and Molecular Sciences Supervisor: Prof. Roland K. O. Sigel, Susann Zelger-Paulus |
| 2021 – 2024 | Master of Science in Physics Thesis : "Investigating the Effect of Liquid-Liquid Phase Separation on the Modification Efficiency of PARP10 for Different Substrates" RWHT Aachen University, Aachen, Germany |
| 2018 – 2021 | Bachelor of Science in Physics Thesis: "Confocal fluorescence detection analysis tools for high affinity bimolecular bindings" RWTH Aachen University, Aachen, Germany |
| 2016 – 2018 | Bachelor of Science in Mechanical Engineering RWTH Aachen University, Aachen, Germany |
Additional Professional Experience
| May 2018 – April 2020 | Research assistant, Institute of Automotive Engineering, RWTH Aachen University, Aachen, Germany |
| June – July 2016 | Internship, Gebr. Steimel GmbH & Co., Hennef Germany |
Awards and Memberships of Professional Societies
| 2016 – Present | German Physical Society (DPG) |
| DPG-Abiturpreis Physik 2016 |
Conferences
Physics of Life 2023, Harrogate, England (Attended)
Young Scientists get-together at the Faculty of Medicine 2023, Aachen, Germany (Attended)
SCS Fall Meeting 2024, Fribourg, Switzerland (Attended)
Publications
B. Schedler, O. Yukhnovets, L. Lindner, A. Meyer, J. Fitter, November 2023, Thermodynamic fingerprints of an ultra-tight nanobody-antigen binding probed by two-colour single-molecule coincidence detection, International Journal of Molecular Sciences