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Department of Chemistry Sigel Lab

Lennart Lindner

Lennart Lindner

Phone
+41 44 63 54679
Room number
Y19-K-46

CV

Education

2024 – Present University of Zurich, Zurich, PhD in Chemistry
2021 – 2024

RWHT Aachen University, Aachen, MSc Physics

  • Grade: 1.4/1.0*
  • Thesis Title: Investigating the Effect of Liquid-Liquid Phase Separation on the Modification Efficiency of PARP10 for Different Substrates

Relevant Modules: Biophysics 1, Optical Methods, Condensed Matter Physics 1+2, Soft matter physics, Single molecules techniques

2018 – 2021

RWTH Aachen University, Aachen, BSc Physics

  • Grade: 2.1/1.0*
  • Thesis Title: Confocal fluorescence detection analysis tools for high affinity bimolecular bindings

Relevant Modules: Statistical Physics, Optics, Data Analysis, Atoms Molecules Nuclei

2016 – 2018 RWTH Aachen University, Aachen, BSc Mechanical Engineering
2008 – 2016

Gymnasium am Ölberg, Königswinter, German Abitur (University entrance certificate)

German Abitur, Final grade 1.4/1.0*, Major in Math and Physic

Research Experience

2022 - 2023

Master student, Department of Biochemistry and Molecular Biology,
RWTH Aachen University

  • Investigated the ability of the protein PARP10 to phase separate in vitro
  • Analysed the modification of Nucleic Acids inside phase separated droplets
  • Established turbidity assays to test different conditions for phase separation and programmed data evaluation script in Python
  • Experienced in planning experiments and general laboratory work
  • Presented and discussed results in internal lab meetings, regular attendance at Institute Colloquia and Journal Clubs
October 2021 – April 2022

Research Assistant, First Institute of Physics (IA),
RWTH Aachen University

  • Continued measurements of Bachelor Thesis
  • Implemented workflow to ensure fully equilibrated samples and programmed data analysis script in MATLAB
  • Tested the effect of different salt concentrations on the dissociation constant
April – July 2021

Bachelor Student, First Institute of Physics (IA),
RWTH Aachen University

  • Investigated the strong binding between complementary single stranded DNA using Brightness Gated Two Colour Coincidence Detection (BTCCD)
  • Build a workflow for binding curve measurements from scratch
  • Programming analysis software in MATLAB to determine the dissociation constant with different model

Teaching Experience

May – July 202

Lab course supervision, RWHT Aachen University

  • Delivered practical sessions for Medicine students in groups of up to 30 students
  • Responsible for prior-experiment preparation, laboratory safety instruction, experiment supervision, and assessment of handed in protocols
2022 - 2024

Studenten bilden Schüler (Undergraduates helping students)

  • Voluntary teaching of high school students from economically weak households
  • Prior preparation of the content for study sessions, searching for additional study material, and helping with homework for the subjects German and Mathematics

Additional Professional Experience

May 2018 – April 2020 Research assistant, Institute of Automotive Engineering,
RWTH Aachen Universit
June – July 2016 nternship, Gebr. Steimel GmbH & Co., Hennef Germany

Awards and Memberships of Professional Societies

2016 – Present German Physical Society (DPG)
  DPG-Abiturpreis Physik 2016

Addisitonal Skills and Courses

Languages: German (native speaker), English (TOEFL iBT Home Test, Score: 110/120, 2021)
IT Skills: Python, MATLAB, Java, MS Office, LaTeX
Seminar Project “Leonardo” – Science Communication (2023)
Participant of the 24th JCNS Laboratory Course in Neutron Scattering (2022)


Conferences

Physics of Life 2023, Harrogate, England (Attended)
Young Scientists get-together at the Faculty of Medicine 2023, Aachen, Germany (Attended)
SCS Fall Meeting 2024, Fribourg, Switzerland (Attended)


Publications

B. Schedler, O. Yukhnovets, L. Lindner, A. Meyer, J. Fitter, November 2023, Thermodynamic fingerprints of an ultra-tight nanobody-antigen binding probed by two-colour single-molecule coincidence detection, International Journal of Molecular Sciences