Research project
I am amazed by biomolecular structures and their intricate dynamics for biological function. HDV-like ribozymes are found in all life forms, but their structure and function are largely unexplored. These ribozymes fold into an intricate 'nested double pseudoknot' and are capable of self-cleavage through a transesterification reaction. Minimal HDV-like ribozymes are shorter variants that lack a base-paired domain but retain HDV-like folding and catalytic activity. I am studying one of the minimal HDV-like ribozymes using NMR spectroscopy to gain insight into its 3D structure and self-cleavage pathway, with the aim of applying this knowledge to the whole class of ribozymes.
Behind the Lab Coat: My Inspirations and Passions
Year I joined the Sigel lab: 2022
My favourite molecule: Porphyrins
Scientist Hero: Venki Ramakrishnan.
If I could go anywhere, I would go to the top of Mount Everest.
Outside the lab, I enjoy going for sports such as tennis, badminton, or football and I regularly go hiking in the Swiss Alps on the weekends.
Education
|
12/2022 – today |
PhD student in the group of Prof. Roland K. O. Sigel |
|
08/2021 – 04/2022 |
Master thesis in biophysical chemistry in the group of Dr. Bharathwaj Sathyamoorthy |
|
07/2017 – 07/2022 |
Integrated BS-MS program in Chemistry |
|
03/2015 - 03/2017 |
Higher Secondary studies specialized in science |
Professional Experience
|
11/2021 – 12/2021 |
Stochasticity in gene expression: Reproduce plots of from 2-stage and 3-stage gene expression models from a research paper on Analytical distributions for stochastic gene expression using python at IISER Bhopal. |
|
05/2021 – 06/2021 |
Internship on Sequential chemical shift assignments of duplex DNAs at IISER Bhopal. |
|
05/2019 – 07/2019 |
Summer Internship on Synthesis and study of 1,8-napthalimide derivatives for AIE properties at IISER Bhopal. |
|
05/2018 – 07/2018 |
Summer Internship on Synthesis of porphyrin derivatives and monitoring its properties with UV spectroscopy at IISER Bhopal. |