Publications

ZORA Publication List

Publications

2024
- Journal Article
  - Berton, Cesare; Klingler, Simon; Prytuliak, Stanislav; Holland, Jason P (2024). New tactics in the design of theranostic radiotracers. npj Imaging, 2(1):23.
  - Cieslik, Patrick A; Klingler, Simon; Nolff, Mirja; Holland, Jason P (2024). Radiolabelled $^{177}$Lu-Bispidine-Trastuzumab for Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancers. Chemistry, 30(14):e202303805.
2023
- Journal Article
  - Schreck, Moritz-Valentin; Burgard, Caroline; Schmidtke, Alexander; Hierlmeier, Ina; Stemler, Tobias; Maus, Stephan; Rosar, Florian; Jung, Martin; Speicher, Andreas; Ezziddin, Samer; Holland, Jason P; Bartholomä, Mark D (2023). Radiometal Complexes as Pharmacokinetic Modifiers: A Potent $^{68}$Ga-Labeled Gastrin-Releasing Peptide Receptor Antagonist Based on the Macrocyclic Metal Chelator NODIA-Me. Molecular Pharmaceutics, 20(12):6463-6473.
  - Hierlmeier, Ina; Guillou, Amaury; Earley, Daniel F; Linden, Anthony; Holland, Jason P; Bartholomä, Mark D (2023). HNODThia: A Promising Chelator for the Development of $^{64}$Cu Radiopharmaceuticals. Inorganic Chemistry, 62(50):20537-20558.
  - Chiti, Lavinia Elena; Park, Brian; d’Orchymont, Faustine; Holland, Jason P; Nolff, Mirja C (2023). Impact of Surgical Lights on the Performance of Fluorescence-Guided Surgery Systems: A Pilot Study. Animals, 13(14):2363.
  - d’Orchymont, Faustine; Holland, Jason P (2023). Cooperative Capture Synthesis of Functionalized Heterorotaxanes─Chemical Scope, Kinetics, and Mechanistic Studies. Journal of the American Chemical Society, 145(23):12894-12910.
  - d’Orchymont, Faustine; Holland, Jason P (2023). Asymmetric rotaxanes as dual-modality supramolecular imaging agents for targeting cancer biomarkers. Communications Chemistry, 6(1):107.
  - Gut, Melanie; Dreier, Birgit; Furler, Sven; Sobek, Jens; Plückthun, Andreas; Holland, Jason P (2023). Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo. RSC Chemical Biology, 4(7):494-505.
  - Chiti, Lavinia Elena; Husi, Benjamin; Park, Brian; Beer, Patricia; d'Orchymont, Faustine; Holland, Jason P; Nolff, Mirja C (2023). Performance of two clinical fluorescence imaging systems with different targeted and non-targeted near-infrared fluorophores: a cadaveric explorative study. Frontiers in Veterinary Science, 10:1091842.
2022
- Journal Article
  - Fay, Rachael; Törő, Imre; Schinke, Anna-Lena; Simic, Branko; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Holland, Jason P (2022). Sortase-Mediated Site-Specific Conjugation and 89Zr-Radiolabeling of Designed Ankyrin Repeat Proteins for PET. Molecular Pharmaceutics, 19(10):3576-3585.
  - d'Orchymont, Faustine; Holland, Jason P (2022). Supramolecular Rotaxane-Based Multi-Modal Probes for Cancer Biomarker Imaging. Angewandte Chemie Internationale Edition, 61:e202204072.
  - Earley, Daniel F; Guillou, Amaury; Klingler, Simon; Fay, Rachael; Gut, Melanie; d'Orchymont, Faustine; Behmaneshfar, Shamisa; Reichert, Linus; Holland, Jason P (2022). Charting the Chemical and Mechanistic Scope of Light-Triggered Protein Ligation. JACS Au, 2(3):646-664.
  - Klingler, Simon; Holland, Jason P (2022). Automated light-induced synthesis of 89Zr-radiolabeled antibodies for immuno-positron emission tomography. Scientific Reports, 12:668.
  - Guillou, Amaury; Nisli, Eda; Klingler, Simon; Linden, Anthony; Holland, Jason P (2022). Photoactivatable Fluorescent Tags for Dual-Modality Positron Emission Tomography Optical Imaging. Journal of Medicinal Chemistry, 65(1):811-823.
  - d'Orchymont, Faustine; Holland, Jason P (2022). A rotaxane-based platform for tailoring the pharmacokinetics of cancer-targeted radiotracers. Chemical Science, 13(43):12713-12725.
  - Guillou, Amaury; Ouadi, Ali; Holland, Jason P (2022). Heptadentate chelates for 89Zr-radiolabelling of monoclonal antibodies. Inorganic Chemistry Frontiers, 9(12):3071-3081.
  - Earley, Daniel F; Esteban Flores, Jose; Guillou, Amaury; Holland, Jason P (2022). Photoactivatable bis(thiosemicarbazone) derivatives for copper-64 radiotracer synthesis. Dalton Transactions, 51(13):5041-5052.
2021
- Journal Article
  - Podvalnyy, Nikita M; Chesnov, Serge; Nanni, Paolo; Gut, Melanie; Holland, Jason P; Hennet, Thierry (2021). Synthesis of photoactivable oligosaccharide derivatives from 1,2-cyclic carbamate building blocks and study of their interaction with carbohydrate-binding proteins. Carbohydrate research, 508:108399.
  - Lamb, Jennifer; Šimaitis, Joris; Halukeerthi, Siriney O; Salzmann, Christoph G; Holland, Jason P (2021). Graphene Nanoflake Antibody Conjugates for Multimodal Imaging of Tumors. Advanced NanoBiomed Research, 1(9):2100009.
  - Guillou, Amaury; Earley, Daniel F; Klingler, Simon; Nisli, Eda; Nüesch, Laura J; Fay, Rachael; Holland, Jason P (2021). The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody. Bioconjugate Chemistry, 32(7):1263-1275.
  - Martin, Sebastian; Tönnesmann, Roswitha; Hierlmeier, Ina; Maus, Stephan; Rosar, Florian; Ruf, Juri; Holland, Jason P; Ezziddin, Samer; Bartholomä, Mark D (2021). Identification, Characterization, and Suppression of Side Products Formed during the Synthesis of [177Lu]Lu-PSMA-617. Journal of Medicinal Chemistry, 64(8):4960-4971.
  - Fay, Rachael; Holland, Jason P (2021). Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging. Chemistry - A European Journal, 27(15):4893-4897.
  - Klingler, Simon; Holland, Jason P (2021). Computational studies on the Carboni-Lindsey reaction. Computational and Theoretical Chemistry, 1197:113161.
  - Earley, Daniel F; Guillou, Amaury; van der Born, Dion; Poot, Alex J; Holland, Jason P (2021). Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry. Molecules, 26(3):764.
  - Martin, Sebastian; Maus, Stephan; Stemler, Tobias; Rosar, Florian; Khreish, Fadi; Holland, Jason P; Ezziddin, Samer; Bartholomä, Mark D (2021). Proof-of-Concept Study of the NOTI Chelating Platform: Preclinical Evaluation of 64Cu-Labeled Mono- and Trimeric c(RGDfK) Conjugates. Molecular Imaging and Biology, 23(1):95-108.
2020
- Journal Article
  - Lamb, Jennifer; d'Orchymont, Faustine; Fay, Rachael; Gribi, Florian; Flores, Jose Esteban; Gut, Melanie; Klingler, Simon; Pires, Patricia; Bühler, Jan; Behmaneshfar, Shamisa; Guillou, Amaury; Earley, Daniel F; Holland, Jason P (2020). Expanding the Chemistry Palette for Radiotracer Synthesis. CHIMIA International Journal for Chemistry, 74(12):946-952.
  - Guillou, Amaury; Earley, Daniel F; Patra, Malay; Holland, Jason P (2020). Light-induced synthesis of protein conjugates and its application in photoradiosynthesis of 89Zr-radiolabeled monoclonal antibodies. Nature Protocols, 15(11):3579-3594.
  - Klingler, Simon; Fay, Rachael; Holland, Jason P (2020). Light-induced radiosynthesis of 89ZrDFO-azepin-onartuzumab for imaging the hepatocyte growth factor receptor. Journal of Nuclear Medicine, 61(7):1072-1078.
  - Guillou, Amaury; Earley, Daniel; Holland, Jason Philip (2020). Light-activated protein-conjugation and 89Zr-radiolabelling with water-soluble desferrioxamine derivatives. Chemistry - A European Journal, 26(32):7185-7189.
  - Fay, Rachael; Linden, Anthony; Holland, Jason P (2020). PhotoTag: Photoactivatable Fluorophores for Protein Labeling. Organic Letters, 22(9):3499-3503.
  - Varlow, Cassis; Murrell, Emily; Holland, Jason P; Kassenbrock, Alina; Shannon, Whitney; Liang, Steven H; Vasdev, Neil; Stephenson, Nickeisha A (2020). Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease. Molecules, 25(4):982.
  - Holland, Jason P (2020). Predicting the Thermodynamic Stability of Zirconium Radiotracers. Inorganic Chemistry, 59(3):2070-2082.
  - Holland, Jason P; Gut, Melanie; Klingler, Simon; Fay, Rachael; Guillou, Amaury (2020). Photochemical Reactions in the Synthesis of Protein–Drug Conjugates. Chemistry - A European Journal, 26(1):33-48.
2019
- Journal Article
  - Brown, Christopher J M; Gotsbacher, Michael P; Holland, Jason P; Codd, Rachel (2019). endo-Hydroxamic Acid Monomers for the Assembly of a Suite of Non-native Dimeric Macrocyclic Siderophores Using Metal-Templated Synthesis. Inorganic Chemistry, 58(20):13591-13603.
  - Gut, Melanie; Holland, Jason P (2019). Synthesis and Photochemical Studies on Gallium and Indium Complexes of DTPA-PEG3-ArN3 for Radiolabeling Antibodies. Inorganic Chemistry, 58(18):12302-12310.
  - Fay, Rachael; Gut, Melanie; Holland, Jason P (2019). Photoradiosynthesis of 68Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors. Bioconjugate Chemistry, 30(6):1814-1820.
  - Holland, Jason P (2019). Radiochemistry and drug synthesis ‘in a flash. Drug Target Review:online.
  - Fay, Rachael; Holland, Jason P (2019). The impact of emerging bioconjugation chemistries on radiopharmaceuticals. Journal of Nuclear Medicine, 60(5):587-591.
  - Patra, Malay; Klingler, Simon; Eichenberger, Larissa S; Holland, Jason P (2019). Simultaneous Photoradiochemical Labeling of Antibodies for Immuno-Positron Emission Tomography. iScience, 13:416-431.
  - Patra, Malay; Eichenberger, Larissa S; Fischer, Gregor; Holland, Jason P (2019). Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET. Angewandte Chemie Internationale Edition, 58(7):1928-1933.
  - Patra, Malay; Eichenberger, Larissa S; Fischer, Gregor; Holland, Jason P (2019). Photochemische Konjugation und Eintopfradiomarkierung von Antikörpern für Immun-PET. Angewandte Chemie, 131(7):1946-1951.
  - Lamb, Jennifer; Fischer, Eliane; Rosillo-Lopez, Martin; Salzmann, Christoph G; Holland, Jason P (2019). Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles. Chemical Science, 10(38):8880-8888.
  - Frei, Angelo; Fischer, Eliane; Childs, Bradley Covington; Holland, Jason P; Alberto, Roger (2019). Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold. Dalton Transactions, 48(39):14600-14605.
  - Eichenberger, Larissa S; Patra, Malay; Holland, Jason P (2019). Photoactive chelates for radiolabelling proteins. Chemical Communications, 55(16):2257-2260.
2018
- Journal Article
  - Läppchen, Tilman; Holland, Jason P; Kiefer, Yvonne; Bartholomä, Mark D (2018). Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me. EJNMMI Radiopharmacy and Chemistry, 3:6.
  - Holland, Jason P (2018). Chemical Kinetics of Radiolabelling Reactions. Chemistry - A European Journal, 24(62):16472-16483.
  - Holland, Jason P (2018). Antibody-based radiopharmaceuticals for imaging and therapy. Journal of Labelled Compounds and Radiopharmaceuticals, 61(9):610.
  - Boros, Eszter; Holland, Jason P (2018). Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers. Journal of Labelled Compounds and Radiopharmaceuticals, 61(9):652-671.
  - Collier, Thomas L; Dahl, Kenneth; Stephenson, Nickeisha A; Holland, Jason P; Riley, Adam; Liang, Steven H; Vasdev, Neil (2018). Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry. Journal of Fluorine Chemistry, 210:46-55.
  - Läppchen, Tilman; Kiefer, Yvonne; Holland, Jason P; Bartholomä, Mark D (2018). In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate-specific membrane antigen targeting vector. Nuclear medicine and biology, 60:45-54.

Pagination

Earlier publications

* Corresponding author, † Co-first author

Journal Articles

Eszter Boros,* Jason P. Holland, Nathaniel Kenton, Nicholas Rotile and Peter Caravan
Macrocycle-based hydroxamate ligands for stable complexation and immunoconjugation of the PET Isotope ⁸⁹Zr

ChemPlusChem, 2016, in press. DOI: 10.1002/cplu.201600003.
Svetlana N. Rylova,* Luigi Del Pozzo, Roswitha Tönnesmann, Anna-Lena Illert, Philipp T. Meyer, Helmut R. Maecke and Jason P. Holland
Immuno-PET imaging of CD-30 positive lymphoma using ⁸⁹Zr-DFO-AC-10

J. Nucl. Med., 2016, 57, 96-102. DOI: 10.2967/jnumed.115.162735.
David E. Hill and Jason P. Holland*
Computational studies on hypervalent iodonium(III) compounds as activated precursors for ¹⁸F radiofluorination of electron-rich arenes

Comput. Theor. Chem., 2015, 1066, 34-56. DOI: 10.1016/j.comptc.2015.05.012.
Steven H. Liang,† Jason P. Holland,† Nickeisha A. Stephenson, Alina Kassenbrock, Benjamin H. Rotstein, Cory Daignault, Rebecca Lewis, Thomas Lee Collier, Jacob M. Hooker and Neil Vasdev*
PET neuroimaging studies of [¹⁸F]CABS13 in a double transgenic mouse model of Alzheimer’s disease and nonhuman primates

ACS Chem. Neurosci., 2015, 6, 535-541. DOI: 10.1021/acschemneuro.5b00055.
Nickeisha A. Stephenson, Jason P. Holland, Alina Kassenbrock, Daniel L. Yokell, Steven H. Liang and Neil Vasdev*
Iodonium ylide mediated radiofluorination of ¹⁸F-FPEB and validation for human use

J. Nucl. Med., 2015, 56, 489-492. DOI: 10.2967/jnumed.114.151332.
David E. Hill, Neil Vasdev and Jason P. Holland*
Evaluating the accuracy of density functional theory for calculating ¹H and ¹³C NMR chemical shifts in drug molecules

Comput. Theor. Chem., 2015, 1051, 161-173. DOI:10.1016/j.comptc.2014.11.007.
Eszter Boros, Alice M. Bowen, Lee Josephson, Neil Vasdev and Jason P. Holland*
Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles

Chem. Sci., 2015, 6(1), 225-236. DOI: 10.1039/C4SC02778G.
Jason P. Holland* and Neil Vasdev
Charting the mechanism and reactivity of zirconium oxalate with hydroxamate ligands using density functional theory: implications in new chelate design

Dalton Trans., 2014, 43, 9872-9884. DOI: 10.1039/C4DT00733F. Highlighted as the “Cover Picture,” July 2014.
Eszter Boros,* Elena Rybak-Akimova, Jason P. Holland, Tyson Rietz, Nicholas Rotile, Francesco Blasi, Helen Day, Peter Müller and Peter Caravan*
Pycup – A bifunctional, cage-like ligand for ⁶⁴Cu radiolabelling

Mol. Pharmaceuticals, 2014, 1(2), 617-629. DOI: 10.1021/mp400686z.
Neeta Pandit-Taskar,† Joseph A. O’Donoghue,† Volkan Beylergil, Serge Lyaschenko, Shutian Ruan, Steven B. Solomon, Jeremy C. Durack, Jorge A. Carrasquillo, Robert A. Lefkowitz, Mithat Gonen, Jason S. Lewis, Jason P. Holland, Sarah M. Cheal, Victor E. Reuter, Joseph R. Osborne, Massimo F. Loda, Peter M. Smith-Jones, Wolfgang A. Weber, Neil H. Bander, Howard I. Scher, Michael J. Morris* and Steven M Larson* ⁸⁹Zr J591 immunoPET imaging in patients with castration-resistant prostate cancer
Eur. J. Nucl. Med. Mol. Imaging, 2014, 41, 2093-2105. DOI: 10.1007/s00259-014-2830-7.
Jason P. Holland, Steven H. Liang, Benjamin H. Rotstein, Thomas Lee Collier, Nickeisha A. Stephenson, Ivan Greguric and Neil Vasdev*
Alternative approaches for PET radiotracer development in Alzheimer’s disease: Imaging beyond plaque

J. Labelled Compds Radiopharm., 2014, 57, 323-331. Highlighted as the “Cover Picture”. 2014. DOI: 10.1002/jlcr.3158.
Benjamin H. Rotstein, Steven H. Liang, Jason P. Holland, Thomas Lee Collier, Jacob M. Hooker, Alan A. Wilson and Neil Vasdev*
¹¹CO₂ Fixation: A renaissance in PET radiochemistry

Chem. Commun., 2013, 49, 5621-5629. DOI: 10.1039/C3CC42236D. Highlighted as the “Cover Picture”. 2013.
Jason P. Holland,* Albert Kang, Susan Cohrs, Svetlana V. Selivanova, Selena Milicevic Sephton, Thomas Betzel, Daniel Frey, Mara Wieser, Rolf Jaussi, Richard A. Kammerer, Roger Schibli and Eliane Fischer*
Synthesis and evaluation of biphenyl derivatives as kinesin spindle protein inhibitors

Chem. Biodiversity, 2013, 10(4), 538-555. DOI: 10.1002/cbdv.201200400.
Yelena Y. Janjigian,†* Nerissa Viola-Villegas,† Jason P. Holland, Vadim Divilov, Greg Carbonetti, Sean Carlin, Erica M. Gomes DaGama, Gabriela Chiosis, Elisa de Stanchina and Jason S. Lewis*
Monitoring afatinib treatment in HER2 positive gastric cancer with ¹⁸F-FDG and ⁸⁹Zr-trastuzumab PET

J. Nucl. Med., 2013, 54, 936-943. DOI: 10.2967/jnumed.112.110239. Featured in a “Health Imaging” press release.
Jason P. Holland,* Michael W. Jones, Susan Cohrs, Roger Schibli and Eliane Fischer*
Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression

Bioorg. Med. Chem., 2013, 21, 496-507. DOI: 10.1016/j.bmc.2012.11.013.
Jason P. Holland, Paul Cumming and Neil Vasdev*
PET imaging of enzymes in the brain

Amer. J. Nucl. Med. Mol. Imaging, 2013, 3(3), 194-216. Link.
Michael J. Evans, Jason P. Holland, Michael G. Doran, Sarah M. Cheal, Carl Campos, Samuel L. Rice, Sean Carlin, Ingo K. Mellinghoff, Charles L. Sawyers and Jason S. Lewis
Imaging tumor burden in the brain with ⁸⁹Zr-transferrin

J. Nucl. Med., 2013, 54(1), 90-95. DOI: 10.2967/jnumed.112.109777. Highlighted as the “Cover Picture,” January 2013.
Jason P. Holland,† Michael J. Evans,† Samuel L. Rice, John Wongvipat, Charles L. Sawyers* and Jason S. Lewis*
Annotating MYC status with ⁸⁹Zr-transferrin imaging

Nature Med., 2012, 18, 1586-1591. DOI: 10.1038/nm.2935. Featured in a SciBX press release.
David Ulmert,† Michael J. Evans,† Jason P. Holland, Samuel L. Rice, John Wongvipat, Kim Pettersson, Per-Anders Abrahamsson, Peter T. Scardino, Steven M. Larson, Hans Lilja, Jason S. Lewis* and Charles L. Sawyers*
Imaging androgen receptor signaling with a radiotracer targeting prostate specific antigen

Cancer Discovery, 2012, 2(4), 320-327. DOI: 10.1158/2159-8290.CD-11-0316. Highlighted as the “Cover Picture,” April 2012. Featured in an AACR video press conference and in a “Spotlight” article.
Jason P. Holland,* Paul Cumming and Neil Vasdev
PET of signal transduction pathways in cancer

J. Nucl. Med., 2012, 53(9), 1333-1336. DOI: 10.2967/jnumed.112.105387.
Linjing Mu, Cindy R. Fischer, Jason P. Holland, Jessica Becaud, P. August Schubiger, Roger Schibli, Simon M. Ametamey,* Keith Graham, Timo Stellfeld, Ludger M. Dinkelborg and Lutz Lehmann
¹⁸F-radiolabeling of aromatic compounds using triarylsulfonium salts

Eur. J. Org. Chem., 2012, 2012(5), 889-892. DOI: 10.1002/ejoc.201101730.
Alessandro Ruggiero,† Jason P. Holland,† Tvrtko Hudolin,† Larissa Shenker, Anna Koulova, Neil H. Bander, Jason S. Lewis and Jan Grimm*
PET imaging of therapy-induced prostate cancer cell death by targeting the internal epitope of prostate specific membrane antigen

J. Nucl. Med., 2011, 52(10), 1608-1615. DOI: 10.2967/jnumed.111.092098.
Jason P. Holland, Guillaume Normand, Alessandro Ruggiero, Jason S. Lewis and Jan Grimm*
Intra-operative imaging of PET radiotracers using Cerenkov luminescence emissions

Mol. Imaging, 2011, 10(3), 177-186. DOI: 10.2310/7290.2010.00047.
Carola Heneweer,† Jason P. Holland,† Vadim Divilov, Sean Carlin and Jason S. Lewis*
Magnitude of enhanced permeability and retention (EPR) effect in tumors with different phenotypes: ⁸⁹Zr-albumin as a model system

J. Nucl. Med., 2011, 52(4), 625-633. DOI: 10.2967/jnumed.110.083998.
Alessandro Ruggiero,† Carlos H. Villa,† Jason P. Holland, Shanna R. Sprinkle, Chad May, Jason S. Lewis, David A. Scheinberg and Michael R. McDevitt*
Imaging and treating tumor vasculature with radiolabeled carbon nanotubes

Int. J. Nanomedicine, 2010, 5, 783-802. DOI: 10.2147/IJN.S13300.
Inmaculada Matas Ruiz, George R. Whittell, Benjamin M. Partridge, Jason P. Holland, Mairi F. Haddow, Jennifer C. Green* and Ian Manners*
Synthesis, electronic structure, and reactivity of nickel-, palladium-, and platinum-bridged [1]ferrocenophanes

J. Amer. Chem. Soc., 2010, 132(38), 13279-13289. DOI: 10.1021/ja103367e.
Jason P. Holland and Jason S. Lewis*
Zirconium-89 chemistry in the design of novel radiotracers for immuno-PET

Technetium and Other Radiometals in Chemistry and Medicine, Eds: Ulderico Mazzi, William C. Eckelman, Wynn A. Volkert, Publisher: Servizi Grafici Editoriali snc, Padova, Italy, 2010, 187-192.
Jason P. Holland, Vadim Divilov, Neil H. Bander, Peter M. Smith-Jones, Steven M. Larson and Jason S. Lewis*
⁸⁹Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo

J. Nucl. Med., 2010, 51(8), 1293-1300. DOI: 10.2967/jnumed.110.076174. Selected as the Journal of Nuclear Medicine’s Editor’s Choice Award for the “Best Basic Science Article,” June 2011.
Alessandro Ruggiero,† Jason P. Holland,† Jason S. Lewis and Jan Grimm*
Cerenkov luminescence imaging of medical isotopes

J. Nucl. Med., 2010, 51(7), 1123-1130. DOI: 10.2967/jnumed.110.076521. Highlighted in a press release by the Society of Nuclear Medicine.
Martin Christlieb,* Jason P. Holland and Jonathan R. Dilworth
Investigation of the UV–Vis absorption of bis(N-methylthiosemicarbazonato) zinc Zn[ATSM]

Inorganica Chim. Acta, 2010, 363(6), 1133-1139. DOI: 10.1016/j.ica.2009.10.006.
Artem Y. Lebedev, Jason P. Holland and Jason S. Lewis*
Clickable bifunctional radiometal chelates for peptide labeling

Chem. Commun., 2010, 46, 1706-1708. DOI: 10.1039/b924784j.
Jason P. Holland,* and Jennifer C. Green
Evaluation of exchange-correlation functionals for time-dependent density functional theory calculations on metal complexes

J. Comput. Chem., 2010, 31(5), 1008-1014. DOI: 10.1002/jcc.21385.
John G. Woollard-Shore, Jason P. Holland, Michael W. Jones* and Jonathan R. Dilworth*
Nitrite reduction by copper complexes

Dalton Trans., 2010, 35, 1576-1585. DOI: 10.1039/b913463h.
Jason P. Holland, Eloisi Caldas-Lopes, Vadim Divilov, Valerie M. Longo, Tony Taldone, Danuta Zatorska, Gabriela Chiosis and Jason S. Lewis*
Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using ⁸⁹Zr-DFO-trastuzumab

PLoS ONE, 2010, 5(1), e8859. DOI: 10.1371/journal.pone.0008859.
Jason P. Holland,* Victoria Fisher, Jennie A. Hickin and Josephine M. Peach*
Pyrene-functionalised copper complexes as potential dual-modality imaging agents

Eur. J. Inorg. Chem., 2010, (1), 48-58. DOI: 10.1002/ejic.200900823. Highlighted as the “Cover Picture,” January 2010.
Jason P. Holland, Matthew J. Williamson and Jason S. Lewis*
Unconventional nuclides for radiopharmaceuticals

Mol. Imaging, 2010, 9(1), 1-20. DOI: 10.2310/7290.2010.00008.
Jason P. Holland,* Michael W. Jones, Paul D. Bonnitcha, Jason S. Lewis and Jonathan R. Dilworth
Functionalised copper-64 bis(thiosemicarbazonato) complexes as precursors of potential PET imaging agents for neurodegenerative disorders

New J. Chem., 2009, 33, 1845-1852. DOI: 10.1039/b902895a. Top 10 New J. Chem. downloaded articles, September 2009.
Jason P. Holland, Yiauchung Sheh and Jason S. Lewis*
Standardized methods for the production of high specific-activity zirconium-89

Nucl. Med. Biol., 2009, 36, 729-739. DOI: 10.1016/j.nucmedbio.2009.05.007. #1 Highest cited article in NMB since 2009.
Peter J. Barnard,* Jason P. Holland, Simon R. Bayly, Thaddeus J. Wadas, Carolyn J. Anderson and Jonathan R. Dilworth*
Macrocyclic diamide ligand systems: potential chelators for ⁶⁴Cu- and ⁶⁸Ga-based positron emission tomography imaging agents

Inorg. Chem., 2009, 48(15), 7117-7126. DOI: 10.1021/ic900307f.
Georgeta Masson, David E. Herbert, George R. Whittell, Jason P. Holland, Alan J. Lough, Jennifer C. Green* and Ian Manners*
Synthesis and reactivity of a silicon-bridged [1]ferroceniumphane

Angew. Chem. Int. Ed., 2009, 48, 4961-4964. DOI: 10.1002/anie.200901213.
Franziska Bell, Jason Holland, Jennifer C. Green* and Michel R. Gagné
Computational studies on the Pt(II)-catalyzed cycloisomerization of 1,6-dienes into bicyclopropanes: A mechanistic quandary evaluated by DFT

Organometallics, 2009, 28, 2038-2045. DOI: 10.1021/om800770x.
Jason P. Holland,* Jeffrey H. Giansiracusa, Stephen G. Bell, Luet-Lok Wong and Jonathan R. Dilworth
In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals

Phys. Med. Biol., 2009, 54, 2103-2119. DOI: 10.1088/0031-9155/54/7/017.
Jason P. Holland,* Peter J. Barnard, Simon R. Bayly, Jonathan R. Dilworth and Jennifer C. Green
Electronic absorption spectroscopy and time-dependent density functional theory calculations on the nickel(II) complex of 1,4-bis(pyrrol-2-ylmethyleneamino)butane

Inorganica Chim. Acta, 2009, 362(2), 402-406. DOI: 10.1016/j.ica.2008.04.031.
Jason P. Holland, Riccardo Ferdani, Carolyn J. Anderson and Jason S. Lewis*
Copper-64-radiopharmaceuticals for oncologic imaging

PET Clinics, 2009, 4(1), 49-67. DOI: 10.1016/j.cpet.2009.04.013.
Jason P. Holland, Jason S. Lewis and Farrokh Dehdashti*
Assessing tumor hypoxia by positron emission tomography with Cu-ATSM

Q. J. Nucl. Med. Mol. Imaging, 2009, 53, 193-200. Link.
Jason P. Holland,* Jennie A. Hickin, Emma Grenville-Mathers, ThaoNguyen Nguyen, and Josephine M. Peach*
Rapid decomplexation of bis(thiosemicarbazonato)zinc(II) complexes using citric acid

J. Chem. Res., 2008, 12, 702-703. DOI: 10.3184/030823408X380731.
Simon R. Bayly, Robert C. King, Davina J. Honess, Peter J. Barnard, Helen M. Betts, Jason P. Holland, Rebekka Hueting, Paul D. Bonnitcha, Jonathan R. Dilworth, Franklin I. Aigbirhio, and Martin Christlieb*
In vitro and in vivo evaluations of a hydrophilic ⁶⁴Cu-bis(thiosemicarbazonato)–glucose conjugate for hypoxia imaging

J. Nucl. Med., 2008, 49, 1862-1868. DOI: 10.2967/jnumed.108.054015.
Helen M. Betts, Peter J. Barnard, Simon R. Bayly, Jonathan R. Dilworth,* Antony D. Gee and Jason P. Holland
Controlled axial ligation: solid-phase synthesis and purification of metallo-radiopharmaceuticals

Angew. Chem. Int. Ed., 2008, 47(44), 8416-8419. DOI: 10.1002/anie.200801936.
Jason P. Holland,* Peter J. Barnard, David Collison, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green,* Julia M. Heslop, Eric J. L. McInnes, Christoph G. Salzmann and Amber L. Thompson
Synthesis, X-ray crystallography, spectroelectrochemistry and computational studies on potential copper-based radiopharmaceuticals

Eur. J. Inorg. Chem., 2008, 3549-3560. Highlighted as a “EurBest” article, 20^th August 2008. DOI: 10.1002/ejic.200800413.
Jason P. Holland, Peter J. Barnard, Jonathan R. Dilworth,* and David J. Watkin
(2-Hydroxyphenylimido-κN)-(methanolate-κO)[2-oxidobenzylideneamino)phenlate-κ²O,N,O']-(triphenylphosphine-κP)rhenium(V)

Acta Crystallogr. E, 2008, E64, m773. DOI: 10.1107/S1600536808010684.
Jason P. Holland,* Peter J. Barnard, David Collison, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green,* and Eric J. L. McInnes
Spectroelectrochemical and computational studies on the mechanism of hypoxia-selectivity of copper radiopharmaceuticals

Chem. Eur. J., 2008, 14, 5890-5907. DOI: 10.1002/chem.200800539.
Jason P. Holland,* Peter J. Barnard, Simon R. Bayly, Helen M. Betts, Grant C. Churchill, Jonathan R. Dilworth,* Ruth Edge, Jennifer C. Green* and Rebekka Hueting
Synthesis, radiolabelling and confocal fluorescence microscopy of styrene derivatised zinc and copper bis(thiosemicarbazonato) complexes

Eur. J. Inorg. Chem., 2008, 1985-1993. DOI: 10.1002/ejic.200701351.
Peter J. Barnard, Simon R. Bayly, Jason P. Holland, Jonathan R. Dilworth* and Philip A. Waghorn
In vitro assays for assessing the stability of new potential copper-based radiopharmaceuticals

Q. J. Nucl. Med. Mol. Imaging, 2008, 52(3), 235-244. Link.
Peter Barnard, Simon Bayly, Helen Betts, Paul Bonnitcha, Martin Christlieb, Jon Dilworth,* Jason Holland and Sofia Pascu
Towards new copper based radiopharmaceuticals

Q. J. Nucl. Med. Mol. Imaging, 2008, 52(2), 174-184. Link.
Andrey Y. Khalimon, Jason P. Holland, Radoslaw M. Kowalczyk, Eric J. L. McInnes, Jennifer C. Green, Philip Mountford* and Georgii Nikonov
Synthesis and molecular and electronic structure of an unusual paramagnetic borohydride complex Mo(NAr)₂(PMe₃)₂(h²-BH₄)

Inorg. Chem., 2007, 47, 999-1006. DOI: 10.1021/ic701826v.
Jason P. Holland, Franklin I. Aigbirhio, Helen M. Betts, Paul D. Bonnitcha, Paul Burke, Martin Christlieb, Grant C. Churchill, Andrew R. Cowley, Jonathan R. Dilworth,* Paul S. Donnelly, Jennifer C. Green, Josephine M. Peach, Sridhar R. Vasudevan and John E. Warren
Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: Synthetic platforms towards site-specific radiopharmaceuticals

Inorg. Chem., 2007, 46, 465-485. DOI: 10.1021/ic0615628.
Jason P. Holland, Jennifer C. Green* and Jonathan R. Dilworth*
Probing the mechanism of hypoxia-selectivity of copper bis(thiosemicarbazonato) complexes: DFT calculation of redox potentials and absolute acidities in solution

Dalton Trans., 2006, 6, 783-794. DOI: 10.1039/b512656h. Highlighted as a “Hot Article” and reviewed in Chemistry World, January 2006.
Andrei S. Batsanov, Jonathan C. Collings, Ian J. S. Fairlamb,* Jason P. Holland, Judith A. K. Howard, Zhenyang Lin, Todd B. Marder,* Alex C. Parsons, Richard M. Ward, and Jun Zhu
Requirement for an oxidant in Pd/Cu co-catalyzed terminal alkyne homocoupling to give symmetrical 1,4-disubstituted 1,3-diynes

J. Org. Chem., 2005, 70, 703-706. DOI: 10.1021/jo048428u.

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Books and Chapters

Jason Holland
Hypoxia-Selective Copper Radiopharmaceuticals: Rational Design of Novel Imaging Agents

VDM-Verlag, Germany, 15^th May 2009. ISBN-13: 978-3-639-15244-9. ISBN-10: 3639152441. (Thesis book)

Brian M. Zeglis, Jason P. Holland, Artem Y. Lebedev, Melchor V. Cantorias and Jason S. Lewis
Radiopharmaceuticals for imaging in oncology with special emphasis on positron-emitting agents

Chapter 3 in Nuclear Oncology – Pathophysiology and Clinical Applications, Eds. H. William Strauss, Giuliano Mariani, Duccio Volterrani, Steven M. Larson. Springer. 2012. ISBN-13: 978-0387488936. ISBN-10: 0387488936. (Book chapter)

Department of Chemistry Jason Holland

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