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Eva Freisinger
Publications
ZORA Publication List
Publications
2026
Journal Article
Buso, G., Mirault, T., Schlager, O., Heiss, C., Boc, V., Brodmann, M., Ageno, W., Barco, S. L., Madaric, J., Belch, J., Müller, O. J., Freisinger, E., Behrendt, C.-A., Korosoglou, G., Czihal, M., Mazzolai, L., Rammos, C., & editorial board of Vasa. (2026).
The year in vascular medicine: Highlights in Vasa - European Journal of Vascular Medicine 2025
Vasa, 55(1), 1–5. https://doi.org/10.1024/0301-1526/a001257
2025
2024
Edited Scientific Work
Sigel, A., Sigel, H., Freisinger, E., Sigel, R. K. O., & Bettencourt-Dias, A. de (Eds.). (2024).
Metal-Containing Molecules and Nanomaterials: From Diagnosis to Therapy
(Vol. 26). CRC Press, Taylor & Francis Group.
2023
Journal Article
Heiss, C., Barco, S., Behrendt, C.-A., Brodmann, M., Freisinger, E., Partovi, S., Rammos, C., Müller, O. J., & Editorial board of Vasa. (2023).
The year in vascular medicine: Highlights in Vasa - European Journal of Vascular Medicine 2022.
Vasa, 52, 3–5. https://doi.org/10.1024/0301-1526/a001048
2022
Journal Article
Łuczkowski, M., Padjasek, M., Ba Tran, J., Hemmingsen, L., Kerber, O., Habjanič, J., Freisinger, E., & Krężel, A. (2022).
An Extremely Stable Interprotein Tetrahedral Hg(Cys)$_{4}$ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH
Chemistry, 28, e202202738. https://doi.org/10.1002/chem.202202738
Book Section
Hafner, J. (2022).
Arteriolosklerose
In U. Hoffmann, N. Weiss, M. Czihal, B. Linnemann, & E. Freisinger (Eds.), Klinische Angiologie (pp. 1–10). Springer. https://doi.org/10.1007/978-3-662-61379-5_90-1
2021
Journal Article
Pullen, S., Hegmans, A., Hiller, W. G., Platzek, A., Freisinger, E., & Lippert, B. (2021).
On the Heterogeneous Nature of Cisplatin‐1‐Methyluracil Complexes: Coexistence of Different Aggregation Modes and Partial Loss of NH 3 Ligands as Likely Explanation
ChemistryOpen, 10, 28–45. https://doi.org/10.1002/open.202000317
2020
Journal Article
Book Section
2019
Journal Article
Steffen, F. D., Börner, R., Freisinger, E., & Sigel, R. K. O. (2019).
Stick, Flick, Click: DNA-guided Fluorescent Labeling of Long RNA for Single-molecule FRET
Chimia, 73, 257–261. https://doi.org/10.2533/chimia.2019.257
2018
Journal Article
Cabral, A. C. S., Jakovleska, J., Deb, A., Penner-Hahn, J. E., Pecoraro, V. L., & Freisinger, E. (2018).
Further insights into the metal ion binding abilities and the metalation pathway of a plant metallothionein from Musa acuminata
Journal of Biological Inorganic Chemistry, 23, 91–107. https://doi.org/10.1007/s00775-017-1513-9
Freisinger, E., & Sigel, R. K. O. (2018).
Celebrating Helmut Sigel
Journal of Biological Inorganic Chemistry, 23, 1–5. https://doi.org/10.1007/s00775-017-1523-7
Zhao, M., Steffen, F. D., Börner, R., Schaffer, M. F., Sigel, R. K. O., & Freisinger, E. (2018).
Site-specific dual-color labeling of long RNAs for single-molecule spectroscopy
Nucleic Acids Research, 46, e13–e13. https://doi.org/10.1093/nar/gkx1100
2017
Journal Article
Cao, Q., Li, Y., Freisinger, E., Qin, P. Z., Sigel, R. K. O., & Mao, Z.-W. (2017).
G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs
Inorganic Chemistry Frontiers, 4, 10–32. https://doi.org/10.1039/C6QI00300A
2016
Journal Article
Egloff, D., Oleinich, I. A., Zhao, M., König, S. L. B., Sigel, R. K. O., & Freisinger, E. (2016).
Sequence-specific post-synthetic oligonucleotide labeling for single-molecule fluorescence applications
ACS Chemical Biology, 11, 2558–2567. https://doi.org/10.1021/acschembio.6b00343
2015
Journal Article
Siebel, S., Dammann, C., Sanz Miguel, P. J., Drewello, T., Kampf, G., Teubner, N., Bednarski, P. J., Freisinger, E., & Lippert, B. (2015).
Analogues of Cis- and Transplatin with a Rich Solution Chemistry:cis-[PtCl2(NH3)(1-MeC-N3)] andtrans-[PtI2(NH3)(1-MeC-N3)]
Chemistry, 21, 17827–17843. https://doi.org/10.1002/chem.201502691
Lüth, M. S., Freisinger, E., Kampf, G., Garijo Anorbe, M., Griesser, R., Operschall, B. P., Sigel, H., & Lippert, B. (2015).
Connectivity patterns and rotamer states of nucleobases determine acid–base properties of metalated purine quartets
Journal of Inorganic Biochemistry, 148, 93–104. https://doi.org/10.1016/j.jinorgbio.2015.02.004
Book Section
Nies, D. H., Freisinger, E., & Krauss, G.-J. (2015).
Excess of metals
In G.-J. Krauss & D. H. Nies (Eds.), Ecological Biochemistry: Environmental and Interspecies Interactions (pp. 237–257). Wiley-VCH. https://doi.org/10.1002/9783527686063.ch12
Nies, D. H., Freisinger, E., & Krauss, G.-J. (2015).
Excess of metals
In G.-J. Krauss & D. H. Nies (Eds.), Ecological Biochemistry: Environmental and Interspecies Interactions (pp. 237–257). Wiley-VCH. https://doi.org/10.1002/9783527686063.ch12
2014
Journal Article
Freisinger, Eva; Sigel, Roland K O (2014).
Preface
Journal of Biological Inorganic Chemistry, 19(S2):699.
Habilitation
2013
Journal Article
Radunsky, C., Megger, D. A., Hepp, A., Kösters, J., Freisinger, E., & Müller, J. (2013).
A family of hydrazone-based nucleosides for use in metal-mediated base pairs
Zeitschrift Für Anorganische Und Allgemeine Chemie, 639, 1621–1627. https://doi.org/10.1002/zaac.201300061
Phongtongpasuk, S., Paulus, S., Schnabl, J., Sigel, R. K. O., Spingler, B., Hannon, M. J., & Freisinger, E. (2013).
Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction
Angewandte Chemie Internationale Edition, 52, 11513–11516. https://doi.org/10.1002/anie.201305079
Freisinger, E., & Vasak, M. (2013).
Cadmium in metallothioneins
Metal Ions in Life Sciences, 11, 339–371. https://doi.org/10.1007/978-94-007-5179-8_11
Phongtongpasuk, S., Paulus, S., Schnabl, J., Sigel, R. K. O., Spingler, B., Hannon, M. J., & Freisinger, E. (2013).
Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction
Angewandte Chemie, 125, 11727–11730. https://doi.org/10.1002/ange.201305079
Loebus, J., Leitenmaier, B., Meissner, D., Braha, B., Krauss, G.-J., Dobritzsch, D., & Freisinger, E. (2013).
The major function of a metallothionein from the aquatic fungus Heliscus lugdunensis is cadmium detoxification
Journal of Inorganic Biochemistry, 127, 253–260. https://doi.org/10.1016/j.jinorgbio.2013.06.001
2012
Journal Article
Seubert, K., Böhme, D., Kösters, J., Shen, W.-Z., Freisinger, E., & Müller, J. (2012).
N-Methyl-2,2’-dipicolylamine domplexes as potential models for metal-mediated base pairs
Zeitschrift Für Anorganische Und Allgemeine Chemie, 638, 1761–1767. https://doi.org/10.1002/zaac.201200089
2011
Journal Article
Galstyan, A., Sanz Miguel, P. J., Wolf, J., Freisinger, E., & Lippert, B. (2011).
Discrete Molecular Squares {[(en)M(CN)]4}4+ Derived from [(en)M(CN)2] (M = PtII, PdII)
European Journal of Inorganic Chemistry, 2011, 1649–1656. https://doi.org/10.1002/ejic.201001216
Galstyan, A., Shen, W. Z., Freisinger, E., Alkam, H., Hiller, W., Sanz Miguel, P. J., Schürmann, M., & Lippert, B. (2011).
Supramolecular Isomerism of 2,2′-Bipyrazine Complexes with cis-(NH3)2PtII: Ligand Rotational State and Sequential Orientation Determine the 3D Shape of Metallacycles
Chemistry, 17, 10771–10780. https://doi.org/10.1002/chem.201101381
Loebus, J., Peroza, E. A., Blüthgen, N., Fox, T., Meyer-Klaucke, W., Zerbe, O., & Freisinger, E. (2011).
Protein and metal cluster structure of the wheat metallothionein domain gamma-Ec-1: the second part of the puzzle
Journal of Biological Inorganic Chemistry, 16, 683–694. https://doi.org/10.1007/s00775-011-0770-2
2010
2009
Journal Article
Peroza, E., Schmucki, R., Güntert, P., Freisinger, E., & Zerbe, O. (2009).
The βE-domain of wheat Ec-1 metallothionein: a metal-binding domain with a distinctive structure
Journal of Molecular Biology, 387, 207–218. https://doi.org/10.1016/j.jmb.2009.01.035
Peroza, E. A., Al Kaabi, A., Meyer-Klaucke, W., Wellenreuther, G., & Freisinger, E. (2009).
The two distinctive metal ion binding domains of the wheat metallothionein Ec-1
Journal of Inorganic Biochemistry, 103, 342–353. https://doi.org/10.1016/j.jinorgbio.2008.11.008
Said, M., Murtaza, G., Freisinger, E., Anwar, S., & Rauf, A. (2009).
(Z)-2-Phenyl-3-pivaloyl-1,1-dipropylguanidine
Acta Crystallographica Section E: Crystallographic Communications, 65, o2073–o2074. https://doi.org/10.1107/S160053680902978X
Book Section
Freisinger, E. (2009).
Metallothioneins in plants
In A. Sigel, H. Sigel, & R. K. O. Sigel (Eds.), Metallothioneins and related chelators (No. 5; Vol. 5, pp. 107–153). Royal Society of Chemistry. https://doi.org/10.1039/9781847559531-00107
2008
Journal Article
Shen, W. Z., Schnebeck, R. D., Freisinger, E., & Lippert, B. (2008).
On the interrelationship of µ-OH bridged dimers, trimers, and tetramers of (en)PtII and their Ag+ adducts
Dalton Transactions, 4044–4049. https://doi.org/10.1039/b802924e
Freisinger, E., Griesser, R., Lippert, B., Moreno-Luque, C. F., Niclós-Gutiérrez, J., Ochocki, J., Operschall, B. P., & Sigel, H. (2008).
Comparison of the surprising metal-ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(isopropyl) esters of H2(6Umpa)
Chemistry, 14, 10036–10046. https://doi.org/10.1002/chem.200800998
2007
Journal Article
Gil Bardají, E., Freisinger, E., Costisella, B., Schalley, C. A., Brüning, W., Sabat, M., & Lippert, B. (2007).
Mixed-Metal (Platinum, Palladium), Mixed-Pyrimidine (Uracil, Cytosine) Self-Assembling Metallacalix[n]arenes: Dynamic Combinatorial Chemistry with Nucleobases and Metal Species
Chemistry, 13, 6019–6039. https://doi.org/10.1002/chem.200601529
Müller, J., Freisinger, E., Lax, P., Megger, D. A., & Polonius, F.-A. (2007).
Interaction of Pt(II) and Pd(II) complexes of terpyridine with 1-methylazoles: A combined experimental and density functional study
Inorganica Chimica Acta, 360, 255–263. https://doi.org/10.1016/j.ica.2006.07.031
2006
Journal Article
Willermann, M., Mulcahy, C., Sigel, R. K. O., Cerdà, M. M., Freisinger, E., Sanz Miguel, P. J., Roitzsch, M., & Lippert, B. (2006).
Pyrazine as a building block for molecular architectures with PtII
Inorganic Chemistry, 45, 2093–2099. https://doi.org/10.1021/ic051966k
2005
2004
2003
Journal Article
Freisinger, E., Fernandes, A., Grollman, A. P., & Kisker, C. (2003).
Crystallographic Characterization of an Exocyclic DNA Adduct: 3,N4-etheno-2′-deoxycytidine in the Dodecamer 5′-CGCGAATTεCGCG-3′
Journal of Molecular Biology, 329, 685–697. https://doi.org/10.1016/S0022-2836(03)00445-5
Beck, B., Schneider, A., Freisinger, E., Holthenrich, D., Erxleben, A., Albinati, A., Zangrando, E., Randaccio, L., & Lippert, B. (2003).
Inter- and intra-molecular condensation patterns of (en)PdII with trans-[a2PtL2]2+ (a = am(m)ine, L = 2-aminopyridine): PtPd3 and Pt2Pd4 species with multiple amide bridges. Unexpected trapping of a pair of nitrate ions by a Pt2Pd4 double cone
Dalton Transactions, 2533–2539. https://doi.org/10.1039/B301708G
2002
Journal Article
Brüning, W., Freisinger, E., Sabat, M., Sigel, R. K. O., & Lippert, B. (2002).
N1 and N3 linkage isomers of neutral and deprotonated cytosine with trans-[(CH3NH2)2PtII]
Chemistry, 8, 4681–4692. https://doi.org/10.1002/1521-3765(20021018)8:20<4681::AID-CHEM4681>3.0.CO;2-P
Brüning, W., Ascaso, I., Freisinger, E., Sabat, M., & Lippert, B. (2002).
Metal-stabilized rare tautomers of nucleobases. 8. Promotion of rare cytosine tautomer upon complex formation with (dien)M2+ (M=Pt, Pd)
Inorganica Chimica Acta, 339, 400–410. https://doi.org/10.1016/S0020-1693(02)00938-6
Kampf, G., Willermann, M., Freisinger, E., & Lippert, B. (2002).
Diplatinum(III) complexes with bridging 1-methylcytosinate ligands and variable axial ligands, including guanine nucleobases
Inorganica Chimica Acta, 330, 179–188. https://doi.org/10.1016/S0020-1693(01)00741-1
Onoa, G. B., Moreno, V., Freisinger, E., & Lippert, B. (2002).
Pd(II)- and Pt(II)-cimetidine complexes. Crystal structure of trans-[Pt(N,S-cimetidine)2]Cl2.12H2O
Journal of Inorganic Biochemistry, 89, 237–247. https://doi.org/10.1016/S0162-0134(01)00416-0
Riera, X., Moreno, V., Freisinger, E., & Lippert, B. (2002).
Pd(II) and Pt(II) (R,S)-3-aminopyrrolidine complexes. Reactions with 9-ethylguanine and study of their antiproliferative activity
Inorganica Chimica Acta, 339, 253–264. https://doi.org/10.1016/S0020-1693(02)00957-X
Sigel, R. K. O., Freisinger, E., Abbate, M., & Lippert, B. (2002).
Hydrogen bonding patterns of 7,9-dimethylguanine and its transplatinum(II) complexes
Inorganica Chimica Acta, 339, 355–365. https://doi.org/10.1016/S0020-1693(02)00962-3
2001
Journal Article
Sigel, R. K. O., Thompson, S. M., Freisinger, E., Glahé, F., & Lippert, B. (2001).
Metal-modified nucleobase sextet: joining four linear metal fragments (trans-a2PtII) and six model nucleobases to an exceedingly stable entity.
Chemistry, 7, 1968–1980. https://doi.org/10.1002/1521-3765(20010504)7:9<1968::AID-CHEM1968>3.0.CO;2-B
Riera, X., Caubet, A., Lopez, C., Moreno, V., Freisinger, E., Willermann, M., & Lippert, B. (2001).
Versatility in the mode of coordination [(C)−, (N,S), (C,N)− or (C,N,S)−] of the Schiff base: C6H5–CH=N–CH2–CH2–SEt to palladium(II). X-ray crystal structures of cis-[Pd{C6H5–CH=N–CH2–CH2–SEt}Cl2] and [Pd{C6H4–CH=N–CH2–CH2–SEt}Cl]
Journal of Organometallic Chemistry, 629, 97–108. https://doi.org/10.1016/S0022-328X(01)00821-X
Moreno-Luque, C. F., Freisinger, E., Griesser, R., Ochocki, J., Lippert, B., & Sigel, H. (2001).
Comparison of the acis-base properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) and some related compounds. Evidence for intramolecular hydrogen-bond formation in aqueous solution between (N1)H and the phosphonate group of 6Umpa2-
Perkin Transactions 2, 10, 2005–2011. https://doi.org/10.1039/b101078f
2000
1998